Asian Pacific Journal of Reproduction
A retrospective analysis of endometrial receptivity array-personalized embryo transfer and its outcome among women with implantation failure
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Abstract:
Objective: To assess whether personalized embryo transfer guided by endometrial receptivity array (ERA) improves implantation and pregnancy rates in women with implantation failure. Methods: This retrospective case-control study was conducted on women with previous implantation failure. The women were divided into two groups, i.e., women who underwent ERA and those who underwent embryo transfer without ERA testing. ERA was performed using Igenomix. ERA results were interpreted as receptive or non-receptive. Women underwent frozen embryo transfer on the 6th day of progesterone (P+5). The primary outcomes were implantation rate, clinical pregnancy rate, abortion rate, and negative pregnancy rate. Results: This study included 229 women with previous implantation failure, with 154 in the ERA group and 75 in the no ERA group. The mean age of the women of the ERA group was (32.2±4.1) years, and that of the no ERA group was (31.5±4.8) years. Women in the ERA group had a higher implantation rate (60.4%) and clinical pregnancy rate (57.1%) compared to those in the no ERA group (48.0% and 46.7%, respectively). In addition, implantation rate of the non- receptive ERA group was higher than the no ERA group (65% vs. 48%), and clinical pregnancy rate was also higher in the non-receptive ERA group than the no ERA group (65% vs. 47%). The abortion rate of the no ERA group was 9% and that of the non-receptive ERA group was 10%. 52% no ERA group women and 35% non-receptive ERA group women had negative pregnancy results. Conclusions: Women who have undergone personalised embryo transfer guided by ERA have a higher clinical pregnancy rate than women who have not after previous implantation failure.
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