Journal of Acute Disease
Association between macrophage inflammatory protein-1β and prognosis of patients with sepsis
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Abstract:
Objective: To evaluate the association between serum levels of macrophage inflammatory protein-1 (MIP-1β) and disease severity as well as 28-day mortality in sepsis patients. Methods: The retrospective study included adult patients with sepsis who were admitted to the emergency department. Demographic characteristics and laboratory parameters measured within 3 hours of admission were compared, including MIP-1β, lactate, procalcitonin, C-reactive protein, Acute Physiology and Chronic Health Evaluation 栻 (APACHE 栻) score, and Sequential Organ Failure Assessment score.
Results: The study included a total of 202 sepsis patients, who were stratified by 28-day outcomes into 61 survivors and 141 non-survivors. MIP-1β levels were significantly higher in the non-survivor group [(196.08v.s.10.75) pg/mL] than in the survivor group [(125.48v.s.4.70) pg/mL, P<.05]. The areas under the receiver operating characteristic curves (AUC) for predicting 28-day mortality were 0.712 for MIP-1β, 0.599 for lactate, and 0.766 for APACHE 栻 score. MIP-1β levels showed a positive correlation with lactate (r=0.172). Binary logistic regression identified MIP-1 β (OR=1.02, 95% CI: 1.01-1.03, P=.001), APACHE 栻 score (OR=1.16, 95% CI: 1.08-1.24, P<.001), and lactate (OR=1.45, 95% CI: 1.08-1.95, P=.01) as independent risk factors for 28-day mortality in sepsis patients.
Conclusions: MIP-1β demonstrates high sensitivity and specificity in predicting poor outcomes in sepsis. MIP-1β, APACHE 栻 score, and lactate are independent risk factors for 28-day mortality in these patients.
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