目的:探讨百令胶囊联合依达拉奉对慢性阻塞性肺病患者免疫功能、抗氧化功能及相关因子水平的影响。方法:收集2016年3月~2018年3月于我院呼吸内科接受治疗的慢性阻塞性肺病患者160例,随机分为对照组与观察组,每组各80例。对照组患者接受依达拉奉治疗；观察组患者接受百令胶囊联合依达拉奉治疗。分别于治疗前后,检测并比较两组患者T淋巴细胞、超氧化物岐化酶(SOD)、血清丙二醛(MDA)、一氧化氮(NO)、血清转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)及基质金属蛋白酶-9(MMP-9)水平。结果:治疗后,对照组及观察组患者CD3⁺、CD4⁺及CD4⁺/CD8⁺、SOD及NO水平均显著升高,CD8⁺、MDA水平显著降低；且治疗后观察组患者T淋巴细胞及抗氧化酶水平变化趋势较对照组患者明显(P＜0.05)。治疗后,对照组及观察组患者血清中TGF-β1、MMP-9及TNF-α水平均明显降低,且观察组上述指标变化趋势较对照组明显(P＜0.05)。结论:百令胶囊联合依达拉奉治疗慢性阻塞性肺病,可显著增强患者免疫功能及抗氧化功能,缓解机体炎症反应,具有较好的临床疗效。

Objective: To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD). Methods:160 patients with COPD who received treatment in the department of respiratory medicine of our hospital from March 2016 to March 2018 were randomly divided into control group and observation group, 80 cases in each group. Patients in the control group received edaravone treatment, while patients in the observation group received bailing capsule combined with edaravone treatment. The levels of T lymphocyte, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) were measured and compared before and after treatment. Result:After treatment, the levels of CD3⁺, CD4⁺, CD4⁺ / CD8⁺, SOD and NO of patients in the control group and the observation group were significantly higher than those before treatment, while the levels of CD8⁺ and MDA were significantly lower than those before treatment. The change trend of the levels of T lymphocyte and antioxidant enzyme of patients in the observation group were significantly more obvious than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and MMP-9 of patients in the control group and the observation group decreased significantly, and the change trend of the above factors of patients in the observation group was more obvious than that in the control group (P<0.05). Conclusion: Bailing capsule combined with edaravone in the treatment of chronic obstructive pulmonary disease can significantly enhance the immune function and antioxidant function of patients, and alleviate inflammation of the body. It has good clinical curative effect.

R563.9

军区医药卫生科研基金课题项目(14MS047)