新型冠状病毒（SARS‑CoV‑2）感染可导致一系列胃肠道损害。相关研究报道了SARS‑CoV‑2感染可导致溃疡性结肠炎的发生和进展，可能与SARS‑CoV‑2感染引发的细胞因子风暴有关。近日，我们还关注了感染SARS‑CoV‑2是否会加重接受生物免疫治疗UC患者的病情以及接种SARS‑CoV‑2疫苗对这些患者是否安全有效等问题。目前，有关SARS‑CoV‑2、SARS‑CoV‑2疫苗和溃疡性结肠炎之间的相互作用机制尚不完全清楚，需要更多的研究进一步明确其中的关系。

Novel coronavirus （SARS‑CoV‑2， SARS‑CoV‑2 for short） infection can cause a series of gastrointestinal damage. Related studies have reported that SARS‑CoV‑2 infection can lead to the occurrence and progression of ulcerative colitis ， which may be related to the cytokine storm caused by SARS‑CoV‑2 infection. Recently， we have also paid attention to whether infection with SARS‑CoV‑2 will aggravate the condition of UC patients receiving biological immunotherapy and whether vaccination with SARS‑CoV‑2 is safe and effective for these patients. At present， the interaction mechanism between SARS‑CoV‑2， SARS‑CoV‑2 vaccine and ulcerative colitis is not fully understood， and more research is needed to further clarify the relationship.

R574.62

第九四〇医院院内基金项目（20yjky020）；火神山医院科研基金面上项目（HSS?217）；甘肃省科技厅社发处临床医学研究中心项目（21JR7RA017）