G蛋白偶联受体124属于黏附性G蛋白偶联受体家族的重要成员。牙周炎是一种慢性炎症性疾病，其病理机制源于微生物群落与宿主免疫应答系统之间的多维度动态失衡。细胞衰老以细胞周期停滞为特征，当衰老细胞持续存在并积累时，可能导致组织功能障碍。细胞衰老与慢性炎症之间存在着密切的联系，这种联系主要通过衰老相关分泌表型介导的促炎因子级联反应实现，形成了一种正向调控机制。本文深入探究G蛋白偶联受体124在牙周细胞衰老进程中的潜在作用机制，以期为调控牙周组织炎症微环境提供坚实的科学依据和创新性的思路启示。

G protein‑coupled receptor 124 is an important member of the adhesion G protein‑coupled receptor family. Periodontitis is a chronic inflammatory disease whose pathological mechanism stems from the multi‑dimensional dynamic imbalance between the microbial community and the host immune response system. Cellular senescence is characterized by cell cycle arrest， which may lead to tissue dysfunction when senescent cells persist and accumulate. There is a close relationship between cellular senescence and chronic inflammation， which is mainly realized through a senescence‑associated secretory phenotype‑mediated cascade of pro‑inflammatory factors， forming a positive regulatory mechanism. This paper mainly reviews the potential mechanism of G protein‑coupled receptor 124 in the process of periodontal cellular senescence， in order to provide a solid scientific basis and innovative ideas for regulating the inflammatory micro‑environment of periodontal tissue.

R781.42

国家自然科学基金青年科学基金项目（82201080）；海南医科大学学术提升支撑计划（XSTS2025027）