Journal of Hainan Medical University
A systematic review and meta‑analysis of erchen decoction and sanzi yangqin decoction in the treatment of chronic bronchitis
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Abstract:
Objective:To systematically evaluate the efficacy and safety of Erchen decoction and Sanzi Yangqin decoction in the treatment of chronic bronchitis.Methods:The randomized controlled trials of Erchen decoction and Sanzi Yangqin decoction in the treatment of chronic bronchitis were collected from CNKI， Wan Fang data， VIP， CBM， Web of Science， PubMed， Cochrane Library， and Embase databases， and the literature was screened from the establishment of the database to March 31，2023， and both clinical registration trials and gray literature were searched. The final included studies were evaluated for quality and risk of bias using the Cochrance risk of bias assessment tool， and meta‑analysis was performed on the final included studies using RevMan 5.3 software.Results:A total of 13 RCTs involving 978 patients， including 490 patients in the treatment group and 488 patients in the control group， were included， and the results of the meta‑analysis showed that the clinical efficacy of Erchen decoction and Sanzi Yangqin decoction intervention for the treatment of chronic bronchitis significantly improved the total clinical efficiency ［OR = 3.71， 95% CI （2.39，5.75）， P < 0.000 01］. In terms of symptoms and signs， it could shorten the cessation time of cough ［MD = -4.73， 95% CI （-5.63， -3.83）， P < 0.000 01］， wheeze cessation time ［MD = -3.78， 95% CI （-4.30， -3.27）， P < 0.000 01］， lung rales disappearance time ［MD = -4.15， 95% CI （-4.82， -3.73）， P < 0.000 01］； in terms of lung function， it improved FEV1 ［MD = 0.33，95%CI （0.25， 0.40）， P < 0.000 01］ and FEV1/FCV ［MD = 16.21，95%CI （1.48， 30.94）， P = 0.03］； in terms of inflammatory factors， it reduced WBC ［MD = -3.02，95%CI （-3.55， -2.50）， P < 0.000 01］， CRP ［MD =-15.79，95%CI （-20.53， -11.04）， P < 0.000 01］， TNF‑α ［MD = -8.96，95%CI （-13.45，-4.46）， P < 0.000 01］. No serious adverse reactions were reported in the included literature.Conclusion:The intervention of Er Chen Tang combined with San Zi Yang Yin Tang for the treatment of chronic bronchitis can significantly improve clinical efficacy， shorten the time to disappearance of cough， wheezing， and pulmonary rales， improve patients' lung function， and reduce patients' inflammatory factor levels， with safety to be further validated， but the methodological quality of the included literature is generally not high and the number of included literature is low， and more high‑quality， more large sample， and multicenter RCTs support.
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Project Supported:
National Natural Science Foundation Projects （81760848； 82160889）； Guangxi University Young and Middle aged Teachers Research Basic Ability Enhancement Project （2021KY310）； Guangxi Medical and Health Key Cultivation Discipline Construction Project
Clc Number:
R259
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