目的:探讨口腔癌患者有关辅助诊断、细胞生存、血管生成及营养支持方面的水平变化及临床意义。方法:选择在我院治疗的50例口腔癌患者作为观察组,选取50例同期体检健康者作为对照组,观察比较两组辅助诊断[包括分泌型免疫球蛋白A(SIgA)、过氧化氢酶(CAT)]、细胞生存[包括生存素(Survivin)、黏着斑激酶(FAK)]、血管生成[包括肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)、尿激酶型纤溶酶原激活剂(uPA)]及营养支持[包括铅(Pb)、镁(Mg)、钙(Ca)、铁(Fe)、锌(Zn)、铜(Cu)]相关指标的表达水平。结果:观察组除SIgA、Mg、Fe及Zn水平显著低于对照组外(P<0.05),CAT、生存素、FAK、VEGF、HGF、uPA、Pb、Ca及Cu水平均显著高于对照组,差异有统计学意义(P<0.05)。结论:口腔癌患者出现唾液黏膜免疫力下降、细胞生存异常情况,容易新生成肿瘤血管,肿瘤细胞及血管内皮细胞增生、迁移及侵袭活跃,微量元素表达方面也出现异常,不利于机体的营养支持,临床中应加强相关指标的检测,以期为该病的早期诊断及治疗提供依据。

Objective: To investigate the changes and clinical significance of auxiliary diagnosis, cell survival, angiogenesis and nutritional support in patients with oral cancer. Methods:50 patients with oral cancer treated in our hospital from June 2016 to September 2017 were selected as the observation group and 50 healthy people as the control group.The expression levels of auxiliary diagnosis[including secretory immunoglobulin A (SIgA), catalase (CAT)], cell survival[including survivin, focal adhesion kinase (FAK)], angiogenesis[including vascular endothelial growth factor (VEGF), hepatocyte growth (HGF), urokinase-type plasminogen activator (uPA)] and nutritional support[including lead (Pb), magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn) and copper (Cu)] related indicators in the two groups were observed and compared. Results: The levels of SIgA[(83.30±6.05)ug/mL], Mg[(1.21±0.17)mmol/L], Fe[(6.75±1.03)mmol/L] and Zn[(87.11±15.31)μg/L] in the observation group were significantly lower than those in the control group (P<0.05), while the levels of CAT[(39.87±9.18) U/mL], survivin[(131.63±10.53) ng/L], FAK[(62.27±5.20) ng/mL], VEGF[(533.73±150.63)ng/L], HGF[(411.32±181.72)ng/L], uPA[(5.12±1.31)mg/L], Pb[(65.55±20.76)μg/L], Ca[(1.55±0.20)mmol/L] and Cu[(14.90±5.30)μmol/L]were significantly higher than that of the control group.The difference was statistically significant (P<0.05).Conclusions: In patients with oral cancer, the immune function of salivary mucosa decreased and cell survival was abnormal.Oral cancer patients is easy to regenerate tumor blood vessels. Tumor cells and vascular endothelial cells are active in proliferation, migration and invasion. The expression of trace elements is also abnormal, which is not conducive to the nutritional support of the body.The relevant indicators should be strengthened in clinical practice, so as to provide evidence for early diagnosis and treatment of the disease.

R739.8

广东省科技计划项目(2012B031800424)