目的:探讨大株红景天联合氧自由基清除剂对急性脑梗死患者神经功能及神经凋亡的影响。方法:选取本院收治的急性脑梗死患者,经随机数表法分为对照组、大株红景天组。对照组在常规治疗同时加入氧自由基清除剂治疗,大株红景天组患者在常规治疗同时接受大株红景天联合氧自由基清除剂治疗。对比两组治疗前(T0)、治疗1周后(T1)、治疗2周后(T2)血清中神经营养指标、神经损伤指标、神经凋亡指标含量的差异。结果:T0时,两组血清中神经营养指标、神经损伤指标、神经凋亡指标含量的差异不显著。T1、T2时,大株红景天组血清中神经营养指标IGF-1、bFGF、BDNF、GDNF的含量高于对照组；血清中神经损伤指标RBP4、H-FABP、SAA、NPY的含量低于对照组；血清中神经凋亡指标Bcl-2的含量高于对照组,Bax、caspase-3的含量低于对照组。结论:急性脑梗死患者接受大株红景天联合氧自由基清除剂治疗,可有效优化患者的神经功能并抑制神经凋亡。

Objective: To investigate the effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction. Methods:The patients with acute cerebral infarction who received treatment in Xi'an Union Hospital between September 2016 and February 2018 were selected as the study subjects and divided into the control group and Sofren injection group by random number table method. Control group received both conventional treatment and oxygen free radical scavenger treatment, and Sofren injection group received both conventional treatment and Sofren injection combined with oxygen free radical scavenger treatment. The differences in serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were compared between the two groups before treatment (T0), after 1 week of treatment (T1), and after 2 weeks treatment (T2). Results:At T0, serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were not significantly different between the two groups. At T1 and T2, serum neurotrophy indexes IGF-1, bFGF, BDNF and GDNF levels of Sofren injection group were higher than those of control group; serum nerve injury indexes RBP4, H-FABP, SAA and NPY levels were lower than those of control group; serum neural apoptosis index Bcl-2 level was higher than that of control group whereas Bax and caspase-3 levels were lower than those of control group. Conclusion: Sofren injection combined with oxygen free radical scavenger therapy can effectively optimize the neural function and inhibit the neural apoptosis in patients with acute cerebral infarction.

R743.3

陕西省自然科学基金(2014D14)