随着生产生活方式的改变、饮食结构的变化以及人口老龄化的加剧,糖尿病的发生率和致残率及致死率有逐年升高的趋势。糖尿病的发病原因有多种,可能与遗传因素、环境因素、饮食习惯等多种因素密切相关。危及糖尿病患者生活质量和生存状态的多为其并发症,其中涉及各种大血管并发症和微血管并发症,如糖尿病心肌病、糖尿病肾病、糖尿病脑病及糖尿病足等。本文对糖尿病肾病、糖尿病视网膜病变和糖尿病足的发病的相关分子机制进行论述,为新药研发和临床治疗提供借鉴。

With the change of production and life style, the change of dietary structure and the aggravation of population aging, the incidence and fatality rate of diabetes mellitus have been increasing year by year. The pathogenesis of diabetes varies and is closely related to many factors, such as genetic factors, environmental factors, eating habits and so on. Those that endanger the life quality and survival of diabetic patients are mostly complications, including various macrovascular complications and microvascular complications, such as diabetic cardiomyopathy, diabetic nephropathy, diabetic encephalopathy and diabetic foot. The related molecular mechanisms of the pathogenesis of diabetic nephropathy, diabetic retinopathy and diabetic foot are discussed in this paper to provide reference for new drug research and clinical treatment.

R587.2

南充市科学技术和知识产权局项目 ([2016]703)