抑郁症的发病日益增多，其发病机制具有复杂性、复发率高等特点，同时发病机制尚未被阐明。不同品系的大、小鼠模型间参考指标存在明显差异，在抑郁症实验造模中容易受性别、造模方式等的影响，因而规范选择大、小鼠品系用于实验研究具有必要性。目前广泛使用的抑郁症大鼠、小鼠模型虽可以满足大多数抑郁症的疾病研究，但随着中医药成分靶点的深入挖掘及中医学辩证论治的诊疗发展，符合中医学证候分型的抑郁症动物模型的完善与成熟，将会对抑郁症的中医学基础研究更具价值。因此，本综述结合当代文献资料对不同大小鼠的品系特点进行总结分析，以期为中医药治疗抑郁症的证候基础研究提供更有力的理论依据。

The incidence of depression is increasing day by day， and its pathogenesis is characterized by complexity and high recurrence rate. In addition， the pathogenesis has not been elucidated. There are significant differences in the reference indicators between rat and mouse models of different strains. As the experimental modeling of depression is easily affected by gender and modelling methods， it is necessary to standardize the selection of rat and mouse strains for experimental research. Although the widely used rat and mouse models of depression can meet the research on most depression diseases， with the in⁃depth study of component targets of traditional Chinese medicine （TCM） and the development of diagnosis and treatment of TCM dialectics， the improvement and maturity of the depression animal model that is in line with TCM syndrome classification will have more research values for the basic research of depression in Chinese medicine. Therefore， we summarize and analyze the characteristics of different strains of rats and mice based on contemporary literature in this review， in order to provide a more powerful theoretical basis for the basic research of syndromes on TCM treatment of depression.

R?332；R749.4

国家自然科学基金地区基金项目（81860805）；广西中医药大学2020年自治区级?硕士研究生科研创新项目（zzqj001）